1999 – Frank Gehry, Gehry Partners LLP, begins design of the new Museum. Design process takes four years 1999-2003.
2004 – Museum construction begins
2005 – August 29 Hurricane Katrina destroys both the new Museum construction as well as the George Ohr Arts and Cultural Center, then current home to the Ohr Museum.
2010 – November 6, Ohr-O’Keefe patron Jerry O’Keefe, Museum architect Frank Gehry and Biloxi Mayor A.J. Holloway cut the ribbon to open Phase I of the new Museum including the Mississippi Sound Welcome Center, IP Casino Resort Spa Exhibitions Gallery, Gallery of African American Art, and the Pleasant Reed Interpretive Center
2012 – City of Biloxi Center for Ceramics opened September 2012.
2013 – Construction underway on the John S. and James L. Knight Gallery (the Pods) scheduled to open in 2014.
2014 – The first Pod opened on July 12, 2014 (George Ohr’s 157th birthday). The remaining three await funding to complete the interiors of the buildings.